The New Agent Orange

Roundup (Monsanto's Glyphosate Based Herbicide)

Roundup (Glyphosate)

Yet another study has been published connecting Monsanto’s Roundup (Glyphosate based herbicide) with deformities in animal vertebrate embryos.

Sadly, it is not only animal studies but actual humans that are now bearing the weight of this chemical catastrophe.

This new study sets out the dangers of continued Glyphosate use in unmistakable terms. Human birth defects is serious business.

One can only speculate as to why the FDA and EPA are not taking joint action to remove Glyphosate based products from the U.S. market.

At Glyphosate levels approximately 1/10 of residuals allowed in Europe frog and chicken embryos suffer abnormalities in bone development particularly in the skull and vertebra.

For baby boomers and Vietnam era veterans this all has a familiar ring.    The same assurances about the safety of Roundup were being foisted on the public about Agent Orange by the same people, Monsanto and the U.S. Government.

A reading of the full study (PDF) catches reports of Venezuelan babies being born in areas of heavy Glyphosate use that are deformed much like Agent Orange babies of decades before.

Abstract: Glyphosate-Based Herbicides Produce Teratogenic Effects on Vertebrates by Impairing Retinoic Acid Signaling

Alejandra Paganelli, Victoria Gnazzo, Helena Acosta, Silvia L. Lpez, and Andrs E. Carrasco*
Laboratorio de Embriologa Molecular, CONICET-UBA, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 3° piso (1121), Ciudad Autnoma de Buenos Aires, Argentina
Chem. Res. Toxicol., 2010, 23 (10), pp 1586–1595
DOI: 10.1021/tx1001749
Publication Date (Web): August 9, 2010
Copyright © 2010 American Chemical Society
* Corresponding author. Phone: +5411 5950 9500 ext. 2216. Fax: +5411 5950 9626. E-mail:

The broad spectrum herbicide glyphosate is widely used in agriculture worldwide. There has been ongoing controversy regarding the possible adverse effects of glyphosate on the environment and on human health.

Reports of neural defects and craniofacial malformations from regions where glyphosate-based herbicides (GBH) are used led us to undertake an embryological approach to explore the effects of low doses of glyphosate in development.

Xenopus laevis embryos were incubated with 1/5000 dilutions of a commercial GBH. The treated embryos were highly abnormal with marked alterations in cephalic and neural crest development and shortening of the anterior-posterior (A-P) axis.

Alterations on neural crest markers were later correlated with deformities in the cranial cartilages at tadpole stages. Embryos injected with pure glyphosate showed very similar phenotypes.

Moreover, GBH produced similar effects in chicken embryos, showing a gradual loss of rhombomere domains, reduction of the optic vesicles, and microcephaly. This suggests that glyphosate itself was responsible for the phenotypes observed, rather than a surfactant or other component of the commercial formulation.

A reporter gene assay revealed that GBH treatment increased endogenous retinoic acid (RA) activity in Xenopus embryos and cotreatment with a RA antagonist rescued the teratogenic effects of the GBH.

Therefore, we conclude that the phenotypes produced by GBH are mainly a consequence of the increase of endogenous retinoid activity. This is consistent with the decrease of Sonic hedgehog (Shh) signaling from the embryonic dorsal midline, with the inhibition of otx2 expression and with the disruption of cephalic neural crest development.

The direct effect of glyphosate on early mechanisms of morphogenesis in vertebrate embryos opens concerns about the clinical findings from human offspring in populations exposed to GBH in agricultural fields.

Source: Chemical Research in Toxicology

Full Study PDF format

According to the post-war Vietnamese government, 4.8 million Vietnamese people were exposed to Agent Orange, resulting in 400,000 deaths and disabilities, and 500,000 children born with birth defects.

Now Monsanto’s Roundup is bringing forth the same types of facial deformities and birth defects in babies that Monsanto’s Agent Orange brought forth decades ago among the Vietnamese.

Unfortunately, this is not new information. Studies have been around (and suppressed) for years on the negative effects of Roundup’s use. Yet, in the U.S. you have to dig, scrap and hunt on the Internet to bring forth the information. (Another Recent Study on Glyphosate’s deforming effects.) You would think we could have learned more from the Agent Orange fiasco 40 years ago.

In case you are wondering what Monsanto’s reaction is to these negative studies call it “attacking the messenger”.

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5 Responses to “The New Agent Orange”

  1. [...] Posts:In Lies We TrustBayer, Birds & BeesThe New Agent OrangeRenamed Aspartame Certified OrganicGMO Beets Ordered Destroyed Posted in Pdazzler Rant Tags: [...]

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  4. Chris Wark says:

    Why am I not surprised…

    Thanks for sharing this Paul!

  5. [...] There have been other alarms raised about Roundup, including a report last year from Argentine scientists who claimed that Roundup can contribute to birth defects in frogs and chickens. [...]

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